Monday, January 14, 2008
Astonishing news about Alzheimer's
ScienceDaily (Jan. 9, 2008) — An extraordinary new scientific study, which for the first time documents marked improvement in Alzheimer’s disease within minutes of administration of a therapeutic molecule, has just been published in the Journal of Neuroinflammation.
This new study highlights the importance of certain soluble proteins, called cytokines, in Alzheimer’s disease. The study focuses on one of these cytokines, tumor necrosis factor-alpha(TNF), a critical component of the brain’s immune system. Normally, TNF finely regulates the transmission of neural impulses in the brain. The authors hypothesized that elevated levels of TNF in Alzheimer’s disease interfere with this regulation. To reduce elevated TNF, the authors gave patients an injection of an anti-TNF therapeutic called etanercept. Excess TNF-alpha has been documented in the cerebrospinal fluid of patients with Alzheimer’s.
The new study documents a dramatic and unprecedented therapeutic effect in an Alzheimer’s patient: improvement within minutes following delivery of perispinal etanercept, which is etanercept given by injection in the spine. Etanercept (trade name Enbrel) binds and inactivates excess TNF. Etanercept is FDA approved to treat a number of immune-mediated disorders and is used off label in the study.
The use of anti-TNF therapeutics as a new treatment choice for many diseases, such as rheumatoid arthritis and potentially even Alzheimer’s, was recently chosen as one of the top 10 health stories of 2007 by the Harvard Health Letter.
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See also:
Health & Medicine
Alzheimer's Research
Crohn's Disease
Diseases & Conditions
Mind & Brain
Alzheimer's
Disorders & Syndromes
Depression
Reference
Rheumatoid Arthritis
Infllammation
Arthritis
Adipose tissue
Monday, January 7, 2008
The Brain
The human brain fascinates all of us, doesn't it? This website takes a stab at entertaining AND explaining what all those little neurons, er, synapses, er, thingamajiggies are doing when you're not looking. The website is divided into sections and they are: 1) Exhibit Tour: "Brain: The World Inside Your Head"; 2) Brain Games: Boost your brain while having fun with three computer games; and 3) Grown-ups: special information for parents, caregivers and educators. VISIT "BRAIN: THE WORLD INSIDE YOUR HEAD." Also try these "brainy" links: Plastelina Interactive Logic Games "Brain Basics" from Brain Connection Mind Tools' "Improve Your Memory" Smartkit - Daily Puzzles To Cross Train Your Brain Stave Puzzles (but only if you enjoy being tormented) 3D Jigsaw Puzzles from Puzzle House Brainbashers.com - thousands of brain teasers, puzzles, riddles, games and optical illusions Make Your Own Puzzles (all kinds) from Discovery.com BrainJuice Puzzles (FAIR WARNING: Don't get started unless you've got the time and attention to spare. If you click on this link, you will be lost in these puzzles for a while. Heh. You've been warned) UNSOLVED PROBLEMS in Number Theory, Logic, and Cryptography Brainline - an idea-generating process in which creative thinkers from around the world collaborate, cross-pollinate, and generate ideas online Reach the top of the ladder by answering fun trivia questions. |
